u1213nutrition

Publications

Publications

2024

  1. Estrada-Meza J, Videlo J, Bron C, Duchampt A, Saint-Béat C, Zergane M, Silva M, Rajas F, Bouret SG, Mithieux G, Gautier-Stein A. (2024) Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits. Mol Metab. Sep 18;89:102036. 
  2. Monteillet L, Perrot G, Evrard F, Miliano A, Silva M, Leblond A, Nguyen C, Terzi F, Mithieux G, Rajas F. (2024) Impaired Glucose Metabolism, Primary Cilium Defects, and Kidney Cystogenesis in Glycogen Storage Disease Type Ia. J Am Soc Nephrol. 2024 Aug 14.
  3. Fabre O, Bailly S, Mithieux G, Legrand R, Costentin C, Astrup A, Pépin JL. (2024). Long-term trajectories of weight loss and health outcomes: protocol of the SCOOP-RNPC nationwide observational study. BMJ Open. Jul 11;14(7):e082575.  
  4. Vily-Petit J, Taki A, Sinet F, Soty M, Guiard B, Zemdegs J, Malleret G, Stefanutti A, Mithieux G, Gautier-Stein A. (2024) Absence of the Peptide Transporter 1 Induces a Prediabetic and Depressive-Like Phenotype in Mice. Neuroendocrinology.Jun 7:1-16.
  5. Vily-Petit J, Soty-Roca M, Silva M, Micoud M, Evrard F, Bron C, Raffin M, Beiroa D, Nogueiras R, Roussel D, Gautier-Stein A, Rajas F, Cota D, Mithieux G. (2024) Antiobesity effects of intestinal gluconeogenesis are mediated by the brown adipose tissue sympathetic nervous system. Obesity (Silver Spring). Apr;32(4):710-722.
  6. Gautier-Stein A, Vily-Petit J, Rajas F, Mithieux G. (2024). Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance. Biochimie. Aug:223:206-214. 
  7. Corporeau C, Le Foll C, Cruciani-Guglielmacci C, Le Stunff H, Mithieux G, Magnan C, Delarue J. (2024). Fish oil minimises feed intake and improves insulin sensitivity in Zucker fa/fa rats. Br J Nutr. Mar 14;131(5):749-761. 

2023

  1. Vily-Petit J, Soty M, Silva M, Micoud M, Bron C, Guérin-Deremaux L, Mithieux G. (2023) Improvement of energy metabolism associated with NUTRIOSE® soluble fiber, a dietary ingredient exhibiting prebiotic properties, requires intestinal gluconeogenesis Food Res Int May;167:112723.
  2. Rutten MGS, Lei Y, Hoogerland JH, Bloks VW, Yang H, Bos T, Krishnamurthy KA, Bleeker A, Koster MH, Thomas RE, Wolters JC, van den Bos H, Mithieux G, Rajas F, Mardinoglu A, Spierings DCJ, de Bruin A, van de Sluis B, Oosterveer MH. (2023) Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia  Cancer Metab. Apr 21;11(1):5.  
  3. Gautier-Stein A, Chilloux J, Soty M, Thorens B, Place C, Zitoun C, Duchampt A, Da Costa L, Rajas F, Lamaze C, Mithieux G. (2023) A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production Mol Metab. Apr;70:101700.
  4. Gautier-Stein A, Mithieux G. (2023) Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution Nat Rev Gastroenterol Hepatol. Mar;20(3):183-194.

2022

  1. Velmurugan G, Ramprasath T, Mithieux G. (2022) Editorial: Human microbiota: A key player in the etiology and pathophysiology of cardiovascular and metabolic diseases Front Cardiovasc Med. Dec 5;9:1081722.
  2. Zekri Y, Guyot R, Suñer IG, Canaple L, Stein AG, Petit JV, Aubert D, Richard S, Flamant F, Gauthier K. (2022) Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice. Elife Nov 14:11:e81996.
  3. Mithieux G. (2022) Intestinal gluconeogenesis: an insulin-mimetic function Biol Aujourdhui.  216(1-2):37-39.
  4. Ramos S, Ademolue TW, Jentho E, Wu Q, Guerra J, Martins R, Pires G, Weis S, Carlos AR, Mahú I, Seixas E, Duarte D, Rajas F, Cardoso S, Sousa AGG, Lilue J, Paixão T, Mithieux G, Nogueira F, Soares MP. (2022) A hypometabolic defense strategy against malaria Cell Metab.  Aug 2;34(8):1183-1200.e12.
  5. La Rose AM, Groenen AG, Halmos B, Bazioti V, Rutten MGS, Krishnamurthy KA, Koster MH, Kloosterhuis NJ, Smit M, Havinga R, Mithieux G, Rajas F, Kuipers F, Oosterveer MH, Westerterp M. (2022) Increased atherosclerosis in a mouse model of glycogen storage disease type 1a Mol Genet Metab Rep.  Apr 21;31:100872.
  6. Mithieux G. (2022) Transcription factor p63, a member of the p53 family of tumour suppressors, regulates hepatic glucose metabolism Gut  Mar;72(3):415-416.  
  7. Mithieux G. (2022) The gut microbiota: stable bioreactor of variable composition? Trends Endocrinol Metab.  Jul;33(7):443-446.  
  8. Joly-Amado A, Soty M, Philippe E, Lacombe A, Castel J, Pillot B, Vily-Petit J, Zitoun C, Mithieux G, Magnan C. (2022) Portal Glucose Infusion, Afferent Nerve Fibers, and Glucose and Insulin Tolerance of Insulin-Resistant Rats J Nutr.  Aug 9;152(8):1862-1871.  

  9. Monteillet L, Labrune P, Hochuli M, Do Cao J, Tortereau A, Miliano AC, Ardon-Zitoun C, Duchampt A, Silva M, Verzieux V, Mithieux G, Rajas F. (2022) Cellular and metabolic effects of renin-angiotensin system blockade on glycogen storage disease type I nephropathy. Hum Mol Genet. Jan 26;12(1):1415.

  10. Vily-Petit J, Barataud A, Zitoun C, Gautier-Stein A, Serino M, Mithieux G. (2022) Intestinal gluconeogenesis shapes gut microbiota, fecal and urine metabolome in mice with gastric bypass surgery Sci Rep. Jan 26;12(1):1415. .

2021

  1. Zhukouskaya VV, Jauze L, Charles S, Leborgne C, Hilliquin S, Sadoine J, Slimani L, Baroukh B, van Wittenberghe L, Danièle N, Rajas F, Linglart A, Mingozzi F, Chaussain C, Bardet C, Ronzitti G. (2021) A novel therapeutic strategy for skeletal disorders: Proof of concept of gene therapy for X-linked hypophosphatemia. Sci Adv. Oct 29;7(44):eabj5018.

  2. Rabiller L, Labit E, Guissard C, Gilardi S, Guiard BP, Moulédous L, Silva M, Mithieux G, Pénicaud L, Lorsignol A, Casteilla L, Dromard C. (2021) Pain sensing neurons promote tissue regeneration in adult mice. NPJ Regen Med. Oct 14;6(1):63.

  3. Monteillet L, Labrune P, Hochuli M, Do Cao J, Tortereau A, Miliano AC, Ardon-Zitoun C, Duchampt A, Silva M, Verzieux V, Mithieux G, Rajas F. (2021) Cellular and metabolic effects of renin-angiotensin system blockade on glycogen storage disease type I nephropathy. Hum Mol Genet. Oct 7:ddab297.

  4. Rabiller L, Robert V, Arlat A, Labit E, Ousset M, Salon M, Coste A, Da Costa-Fernandes L, Monsarrat P, Ségui B, André M, Guissard C, Renoud ML, Silva M, Mithieux G, Raymond-Letron I, Pénicaud L, Lorsignol A, Casteilla L, Dromard Berthézène C, Cousin B. (2021) Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis. NPJ Regen Med. Aug 3;6(1):41.

  5. La Rose AM, Bazioti V, Hoogerland JA, Svendsen AF, Groenen AG, van Faassen M, Rutten MGS, Kloosterhuis NJ, Dethmers-Ausema B, Nijland JH, Mithieux G, Rajas F, Kuipers F, Lukens MV, Soehnlein O, Oosterveer MH, Westerterp M. (2021) Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia. Mol Metab. Jun 4;53:101265.

  6. Jingsong Cao, Minjung Choi, Eleonora Guadagnin,  Maud Soty,  Marine Silva,  Vincent Verzieux,  Edward Weisser,  Arianna Markel,  Jenny Zhuo,  Shi Liang,  Ling Yin,  Andrea Frassetto,  Anne-Renee Graham,  Kristine Burke,  Tatiana Ketova,  Cosmin Mihai,  Zach Zalinger,  Becca Levy,  Gilles Besin,  Meredith Wolfrom,  Barbara Tran,  Christopher Tunkey,  Erik Owen,  Joe Sarkis,  Athanasios Dousis,  Vladimir Presnyak,  Christopher Pepin,  Wei Zheng,  Lei Ci,  Marjie Hard,  Edward Miracco,  Lisa Rice,  Vi Nguyen,  Mike Zimmer,  Uma Rajarajacholan,  Patrick F. Finn,  Gilles Mithieux,  Fabienne Rajas,  Paolo G. V. Martini &  Paloma H. Giangrande (2021) mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease. Nat Commun 12, 3090.

  7. Estrada-Meza J, Videlo J, Bron C, Saint-Béat C, Silva M, Duboeuf F, Peyruchaud O, Rajas F, Mithieux G, Gautier-Stein A. (2021) Tamoxifen treatment in the neonatal period affects glucose homeostasis in adult mice in a sex-dependent manner. Endocrinology Jul 1;162(7):bqab098

  8. Hoogerland JA, Peeks F, Hijmans BS, Wolters JC, Kooijman S, Bos T, Bleeker A, van Dijk TH, Wolters H, Gerding A, van Eunen K, Havinga R, Pronk ACM, Rensen PCN, Mithieux G, Rajas F, Kuipers F, Reijngoud DJ, Derks TGJ, Oosterveer MH. (2021) Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia. J Inherit Metab Dis. doi: 10.1002/jimd.12380. Online ahead of print.

  9. Sinet F, Soty M, Zemdegs J, Guiard B, Estrada J, Malleret G, Silva M, Mithieux G, Gautier-Stein A. (2021) Dietary Fibers And Proteins Modulate Behavior Via The Activation Of Intestinal Gluconeogenesis. Neuroendocrinology Jan 11. doi: 10.1159/000514289

  10. Soty M, Vily-Petit J, Castellanos-Jankiewicz A, Guzman-Quevedo O, Raffin M, Clark S, Silva M, Gautier-Stein A, Cota D, Mithieux G. (2020) Calcitonin gene-related peptide-induced phosphorylation of STAT3 in arcuate neurons is a link in the metabolic benefits of portal glucose Neuroendocrinology 111(6):555-567.

  11. Gautier-Stein A, Rajas F, Mithieux G. (2021) Intestinal gluconeogenesis and protein diet: future directions. Proc Nutr Soc. May;80(2):118-125.

2020

  1. Rajas F, Dentin R, Cannella A, Silva M, Raffin M, Levavasseur F, Gautier-Stein A, Postic C, Mithieux G. (2020) The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice. Mol Metab. Oct 31:101108.

  2. Blaak EE, Canfora EE, Theis S, Frost G, Groen AK, Mithieux G, Nauta A, Scott K, Stahl B, van Harsselaar J, van Tol R, Vaughan EE, Verbeke K. (2020) Short chain fatty acids in human gut and metabolic health. Benef Microbes. Sep 1;11(5):411-455.

  3. Carper D, Coué M, Nascimento EBM, Barquissau V, Lagarde D, Pestourie C, Laurens C, Petit JV, Soty M, Monbrun L, Marques MA, Jeanson Y, Sainte-Marie Y, Mairal A, Déjean S, Tavernier G, Viguerie N, Bourlier V, Lezoualc’h F, Carrière A, Saris WHM, Astrup A, Casteilla L, Mithieux G, van Marken Lichtenbelt W, Langin D, Schrauwen P, Moro C. (2020) Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis. Cell Rep. Aug 25;32(8):108075.

  4. Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey J, Jeggo R, Jhamandas JH, Kann O, la Cour CM, Martin WF, Mithieux G, Moreira PI, Murphy MP, Nave KA, Nuriel T, Oliet SHR, Saudou F, Mattson MP, Swerdlow RH, Millan MJ. (2020) Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discovery. Sep;19(9):609-633.

  5. Mithieux G. (2020)  Sensing of blood glucose by the nervous system: why, where, how? Ann Biol Clin (Paris)  Apr 1;78(2):134-138.

  6. Vily-Petit J, Soty-Roca M, Silva M, Raffin M, Gautier-Stein A, Rajas F, Mithieux G. (2020) Intestinal gluconeogenesis prevents obesity-linked liver steatosis and non-alcoholic fatty liver disease. Gut Dec;69(12):2193-2202.

  7. Lei Y, Hoogerland JA, Bloks VW, Bos T, Bleeker A, Wolters H, Wolters JC, Hijmans BS, van Dijk TH, Thomas R, van Weeghel M, Mithieux G, Houtkooper RH, de Bruin A, Rajas F, Kuipers F, Oosterveer MH.(2020) Hepatic ChREBP activation limits NAFLD development in a mouse model for Glycogen Storage Disease type Ia. Hepatology Nov;72(5):1638-1653.

  8. Gutierrez-Repiso C, Ho-Plagaro A, Santiago-Fernandez C, Garcia-Serrano S, Rodríguez-Pacheco F, Valdes S, Garrido-Sanchez L, Rodríguez-Díaz C, López-Gómez C, Moreno-Ruiz FJ, Alcain-Martinez G, Gautier-Stein A, Mithieux G, Garcia-Fuentes E. (2020) Jejunal Insulin Signalling Is Increased in Morbidly Obese Subjects with High Insulin Resistance and Is Regulated by Insulin and Leptin. J Clin Med  Jan 10;9(1):196.

  9. Barataud A, Vily-Petit J, Goncalves D, Zitoun C, Duchampt A, Philippe E, Gautier-Stein A, Mithieux G. (2020) Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses. Mol Metab Jan;31:14-23.

  10. Saeed A, Hoogerland JA, Wessel H, Heegsma J, Derks TGJ, van der Veer E, Mithieux G, Rajas F, Oosterveer MH, Faber KN.  (2020) Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels.Hum Mol Genet 2020 Jan 15;29(2):264-273.

2019

  1. Kang HR, Gjorgjieva M, Smith SN, Brooks ED, Chen Z, Burgess SM, Chandler RJ, Waskowicz LR, Grady KM, Li S, Mithieux G, Venditti CP, Rajas F, Koeberl DD. (2019) Pathogenesis of Hepatic Tumors following Gene Therapy in Murine and Canine Models of Glycogen Storage Disease. Mol Ther Methods Clin Dev Nov 11;15:383-391.
  1. Rajas F, Gautier-Stein A, Mithieux G. (2019) Glucose-6 Phosphate, A Central Hub for Liver Carbohydrate Metabolism. Metabolites Nov 20;9(12)
  1. Jauze L, Monteillet L, Mithieux G, Rajas F, Ronzitti G. (2019) Challenges of Gene Therapy for the Treatment of Glycogen Storage Diseases Type I and Type III. Hum Gene Ther Oct;30(10):1263-1273. 
  1. Gjorgjieva M, Mithieux G, Rajas F. (2019) Hepatic stress associated with pathologies characterized by disturbed glucose production. Cell Stress Jan 28;3(3):86-99.  Review.
  1. Hoogerland JA, Lei Y, Wolters JC, de Boer JF, Bos T, Bleeker A, Mulder NL, van Dijk TH, Kuivenhoven JA, Rajas F, Mithieux G, Haeusler RA, Verkade HJ, Bloks VW, Kuipers F, Oosterveer MH. (2019) Glucose-6-phosphate regulates hepatic bile acid synthesis in mice. Hepatology Dec;70(6):2171-2184.

2018

  1. Gjorgjieva M, Calderaro J, Monteillet L, Silva M, Raffin M, Brevet M, Romestaing C, Roussel D, Zucman-Rossi J, Mithieux G and Rajas F. (2018) Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia. J Hepatol. 69:1074-1087.
  1. Gjorgjieva M, Monteillet L, Calderaro J, Mithieux G & Rajas F. (2018) Polycystic kidney features of the renal pathology in glycogen storage disease type 1: possible evolution to renal neoplasia. J.Inherit. Metab. Dis., 41:955-963.
  1. Kaneko K, Soty M, Zitoun C, Duchampt A, Silva M, Philippe E, Gautier-Stein A, Rajas F & Mithieux G. (2018) The role of kidney in the inter-organ coordination of endogenous glucose production during fasting. Mol. Metab.16:203-212.
  1. Monteillet L*, Gjorgjieva M*, Silva M, Verzieux V, Imikirene L, Duchampt A, Guillou H, Mithieux G & Rajas F. (2018). Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Mol. Metab. 16:100-115. * co-authors.
  1. Pursell N, Gierut J, Zhou W, Dills M, Diwanji R, Gjorgjieva M, Saxena U, Yang J-S, Shah A, Venkat N, Storr R, Kim B, Wang W, Abrams M, Raffin M, Mithieux G, Rajas F, Dudek H, Brown BD & Lai C. (2018) Inhibition of glycogen synthase II with RNAi prevents liver injury in mouse models of glycogen storage diseases. Mol. Ther. 26:1771-1782.
  1. Rekha B, Velmurugan G, Freddy AJ, Anusha S, Ramprasath T, Karthik KV, Suresh S, Kulshrestha P, Mithieux G, Lyon AR, Selvam GS, Ramasamy S. (2018) Chronic intake of 4-Methylimidazole induces Hyperinsulinemia and Hypoglycaemia via Pancreatic Beta Cell Hyperplasia and Glucose Dyshomeostasis. Sci Rep. 8:17037 1-13.
  1. Roseman DS, Khan T, Rajas F, Jun LS, Asrani KH, Isaacs C & Farelli JD. (2018) G6PC mRNA therapy positively regulates fasting blood glucose and decreases liver abnormalities in a mouse model of glycogen storage disease 1a. Mol. Ther. 26:814-821.
  1. Vidal P, Pagliarani S, Colella P, Costa Verdera H, Jauze L, Gjorgjieva M, Puzzo F, Marmier S, Collaud F, Sola MS, Charles S, Lucchiari S, Van Wittenberghe L, Vignaud A, Gjata B, Richard I, Laforet P, Malfatti E, Mithieux G, Rajas F, Comi GP, Ronzitti G & Mingozzi F. (2018) Rescue of GSDIII phenotype with gene transfer requires liver- and muscle-targeted GDE expression. Mol. Ther., 26:890-901.
  1. De Vadder F, Mithieux G.(2018) Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate.  J. Endocrinol., 236: R105-R108.
  1. Mithieux G.(2018) Does Akkermansia muciniphila play a role in type 1 diabetes? Gut, 67:1373-1374.
  1. Mithieux G.(2018) Gut nutrient sensing and microbiota function in the control of energy homeostasis. Curr Opin Clin Nutr Metab Care, 21:273-276.
  1. Mithieux G.(2018) Gut Microbiota and Host Metabolism: What Relationship. Neuroendocrinology 106:352-356.
  1. Gjorgjieva M, Mithieux G & Rajas F. (2019) Hepatic stress associated with pathologies characterized by disturbed glucose production. Cell Stress 3:86-99

2017

  1.  Barataud A, Goncalves D, Vinera J, Zitoun C, Duchampt A, Gautier-Stein A & Mithieux G. (2017) Absence of role of dietary protein sensing in the metabolic benefits of duodenal-jejunal bypass in the mouse. Sci. Rep., 23:44856.

  2. Peeks F, Steunenberg TAH, de Boer F, Rubio-Gozalbo ME, Williams M, Burghard R, Rajas F, Oosterveer MH, MH, Weinstein DA and Derks TGJ. (2017) Clinical and biochemical heterogeneity between patients with glycogen storage disease type 1A: the added value of CUSUM for metabolic control. Inherit. Metab. Dis, 40:695-702.

  3. Velmurugan G, Ramprasath T, Swaminathan K, Mithieux G, Rajendhran J, Dhivakar M, Parthasarathy A, Babu V, Thumburaj LJ, Freddy AJ, Dinakaran V, Puhari SSM, Rekha B, Christy JC, Anusha S, Divya G, Suganya K, Meganathan B, Kalyanaraman N, Vasudevan V, Kamaraj R, Karthik M, Jeyakuma B, Abhishek A, Paul E, Pushpanathan M, Rajmohan RK, Velayutham K, Lyon AR & Ramasamy S. (2017) Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis. Genome Biol. 18:8-25

  4. Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schäuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP. (2017) Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell, 169:1263-1275.

  5. Velmurugan G, Ramprasath T, Mithieux G, Swaminathan K & Ramasamy S. (2017) Gut Microbiota, Endocrine Disruption Chemicals, and Diabetes Epidemic Trends Endocrinol Metab 28(8):612-625.

  6. Soty M, Gautier-Stein A, Rajas F & Mithieux G. (2017) Gut-brain glucose signaling in energy homeostasis. Cell Metab, 25:1231-1242.

2016

  1. Casteras S, Abdul-Wahed A, Soty M, Vulin F, Guillou H, Campana M, Le Stunff H, Pirola L, Rajas F, Mithieux G, Gautier-Stein A. The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice. Diabetologia.2016, 59(12):2645-2653.

  2.  Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W. Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.Sci Rep.2016, 6:20127.

  3. Lee YS, De Vadder F, Tremaroli V, Wichmann A, Mithieux G, Bäckhed F. Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production. Mol Metab. 2016, 5(4):263-70.

  4. Soty M, Chilloux J, Delalande F, Zitoun C, Bertile F, Mithieux G, Gautier-Stein A. Post-Translational Regulation of the Glucose-6-Phosphatase Complex by Cyclic Adenosine Monophosphate Is a Crucial Determinant of Endogenous Glucose Production and Is Controlled by the Glucose-6-Phosphate Transporter. J Proteome Res. 2016, 15(4):1342-9.

  5. Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H. Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 2016, 65(7):1202-14. 

  6. De Vadder F., Kovatcheva-Datchary P., Zitoun C., Duchampt A., Bäckhed F., and Mithieux G. Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis. Cell Metab. 2016 24(1):151-7

  7. Gjorgjieva M., Raffin M., Duchampt A., Perry A., Stefanutti A., Brevet M., Tortereau A., Dubourg L., Hubert-Buron A., MabilleM., Pelissou C., Lassalle L., Labrune P., Mithieux G. and Rajas F. Progressive development of renal cysts in glycogen storage disease type I. Hum Mol Gen

  8. Gautier-Stein A & Mithieux G (2016) Le Point Sur : L’axe intestin-cerveau en santé métabolique. Nutrition & Endocrinologie, 14: 58-61.

  9. Gjorgjieva, M., Oosterveer MH, Mithieux G, Rajas F. Mechanisms by which metabolic reprogramming in GSDa liver generates a favorable tumorigenic environment. JIEMS, 2016,4 :1-10.

2015

  1.  De Vadder F, Plessier F, Gautier-Stein A, Mithieux G.Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis. Neurogastroenterol Motil.2015, 27(3):443-8.

  2. Goncalves D, Barataud A, De Vadder F, Vinera J, Zitoun C, Duchampt A, Mithieux G.Bile Routing Modification Reproduces Key Features of Gastric Bypass in Rat.Ann Surg.2015, 262(6):1006-15.

  3. ClarJ, Mutel E, Gri B, Creneguy A, Stefanutti A, Gaillard S, Ferry N, Beuf O, Mithieux G, Nguyen TH, Rajas F. Hepatic lentiviral gene transfer prevents the long-term onset of hepatic tumours of glycogen storage disease type 1a in mice. Hum Mol Genet. 2015, 15;24(8):2287-96.

  4. Soty M., Penhoat A., Amigo-Correig M., Vinera J., Sardella A., Vullin-Bouilloux F., Zitoun C., Houberdon I., Mithieux G. A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health.Mol Metab.2015, 4:106-117

  5. De Vadder F & Mithieux G.(2015) Contrôle de la glycémie par l’axe nerveux intestin-cerveau. Medecine/Sciences,31: 168-173.

  6. Bruyère O, Ahmed HS, Atlan C, Belegaud J, Bortolotti M, Canivenc-Lavier MC, Charrière S, Girardet JP, Houdard S, Kalonji E, Nadaud P, Rajas F, Slama G & Margaritis I. (2015) Review of the nutritional benefits and risks related to intense sweeteners. Archives of Public Health, 73: 1-10.

  7. Rajas F, Clar J, Gautier-Stein A & Mithieux G.(2015) Lessons from new mouse models of glycogen storage disease type 1a in relation to the time course and organ specificity of the disease. J. Inhert. Metab. Dis.38: 521-527.

2014

  1. Mithieux G. (2014) Crosstalk between extrinsic gastrointestinal neurons and the brain in the control of food intake. Best Practice & Research – Clinical Endocrinology & Metabolism, 28: 739-744.

  2.  Mithieux G.Nutrient Control of Energy Homeostasis Via Gut-Brain Neural Circuits. Neuroendocrinology. 2014, 100(2-3):89-94

  3. Mithieux G.Crosstalk between gastrointestinal neurons and the brain in the control of food intake. Best Pract Res Clin Endocrinol Metab. 2014, 28(5):739-44.

  4.  Mithieux G. Metabolic effects of portal vein sensing. Diabetes Obes Metab. 2014, Suppl 1:56-60.

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  8. De Vadder, F., P. Kovatcheva-Datchary, D. Goncalves, J. Vinera, C. Zitoun, A. Duchampt, F. Backhed, and G. Mithieux, Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.Cell, 2014. 156(1-2): p. 84-96.

  9.   Mithieux, G., Nutropioids regulate gut-brain circuitry controlling food intake. Front Horm Res, 2014. 42:155-62.

  10.  Mithieux, G. and A. Gautier-Stein, Intestinal glucose metabolism revisited.Diabetes Res Clin Pract, 2014. 105(3):295-301.

  11. Penhoat, A., L. Fayard, A. Stefanutti, G. Mithieux, and F. Rajas, Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice.Metabolism, 2014. 63(1):104-11.

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